Animal Models for Hepatic Fibrosis and Cirrhosis

Authors: Sherine A Mohammed and Eman E Abu-Deif

Volume 2, Issue 1

Abstract

Liver cirrhosis represents a major health problem. No effective anti-fibrotic therapy is available up till now. Understanding the pathogenesis of liver fibrosis is essential for developing new strategies for anti- fibrotic therapies. Animal models may be used for this purpose [1,2]. Animal models have several advantages compared to clinical studies including; the possibility of taking samples at different time-points, the ability to control variables that cannot be controlled in humans, and the ability to study the implication of specific genes by using genetically modified animals [3]. 

Keywords:

View PDF