Type 1 Interferon Dynamics in Bacterial Infection

Authors: Tania Rahman* and Ferdous Seraj

DOI: 10.23880/jidtm-16000120

Volume 2, Issue 3

Abstract

Several reports have demonstrated that bacteria can induce type I interferon in infected cells and that IFN-I may help control bacterial infection. Moreover, type I IFN play an essential role in the immune homeostasis of gastrointestinal tract and maintain barrier integrity in endothelial cells. Also pDC produce large amount of type I IFN due to their constitutive expression of the transcription factor IRF-7. The work presented here has unravelled the potential of type 1 IFN in the immune system including various subtypes, their production by different cell types and their host defense against bacterial pathogens. These findings would help set up future avenues of research to elucidate a key mechanism of action of these cells and provide new therapeutic insights.

Keywords: IFNAR1; IFNAR2; pDC; ISG; TLR4-TRIF pathway; TLR4-TRIF pathway; IFNAR1-/- mice

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