Clinical Failure in Patients Receiving Outpatient Parenteral Antimicrobial Therapy (OPAT) with Vancomycin Compared to Daptomycin or Ceftaroline

Authors: Moenster R , Stoneking C and Lin neman T

DOI: 10.23880/jidtm-16000122

Volume 2, Issue 3

Abstract

Purpose: The purpose of this study was to determine if vancomycin therapy was associated with higher rates of clinical failure compared to those treated with daptomycin or ceftaroline therapy (DCT) in patients receiving outpatient parenteral antimicrobial therapy (OPAT). Methods: This was a retrospective, single center cohort study including patients who received â \(≥\) 7 days of OPAT with vancomycin, ceftaroline, or daptomycin from 01/01/2009 through 03/31/2016 at the VA Saint Louis Healthcare System. The primary outcome was clinical failure, defined as a composite of acute kidney injury (AKI), creatinine phosphokinase elevations ≥ 500 units/L, adverse drug events necessitating a change in therapy, readmission due to recurrence of infection, or reinitiation of antibiotics after discontinuation. Multivariate logistic regression was used to evaluate independent risk factors for clinical failure. 

Keywords: Anti-Infective Agents; Home Infusion Therapy; Methicillin-Resistant Staphylococcus Aureus; Outpatient Parenteral Antimicrobial Therapy

View PDF