ISSN: 2474-9230
Authors: Sonuga AA*, Asaolu MF, Oyeyemi AO and Sonuga OO
Background: Oxidative stress plays a causative role in the pathophysiology of preeclampsia. This study aimed at assessing the effects of vitamin D supplementation on the antioxidant status and lipid peroxidation product of preeclamptic women. Methods: Ninety women between ages of 18 and 35 were recruited at 22weeks gestation from antenatal Clinic in Obstetrics and Gynecology Department of University College Hospital Ibadan, and Adeoyo Maternity Clinic, Yemetu, Nigeria. 30 normotensive pregnant women were grouped into Group A, and 60 preeclamptic women randomly grouped into Group B and Group C. Group C was given 1000IU/day of Vitamin D3 for 8weeks after recruitment at 22 weeks. Serum concentration of antioxidants were done by standard methods at 22 weeks, 30 weeks after supplementation and postpartum in all groups. They were followed up 3-7days postpartum, and obstetric data collected. Statistical analysis was done by using Statistical Package for Social sciences (SPSS) soft version 17.0. Results: There was no significant difference (p>0.05) in gestational age at delivery, weight of fetus between the three groups, while there was a significant increase (p<0.05) in BMI, systolic and diastolic blood pressure in group B and C. The level of Malonaldehyde (MDA) was significantly higher (p<0.05), while SOD, GPX and catalase were lower in the preeclamptic groups at 2nd trimester when compared with control. After supplementation the MDA levels reduced significantly (p<0.05), while SOD, GPX and catalase increased significantly (p<0.05) in 3rd trimester and postpartumly in the supplemented group when compared with non-supplemented group. Vitamin C levels were not statistically different (p>0.05) at 2nd, 3rd trimester and postpartum, while Vit. E was significantly reduced (p<0.05) at the 3rd trimester in the control group. The level of Vit. E was significantly increased (p<0.05), while Vit. C level was not statistically different (p>0.05) at 2nd trimester in the PE groups when compared with control. After supplementation, a significant increase (p<0.05) occurred in Vit. E, while Vit. C level was not statistically different (p>0.05) when compared with the nonsupplemented PE group. Conclusion: Vitamin D supplementation is important in improving the antioxidant status in Preeclampsia.
Keywords: Preeclampsia; Vitamin D; Antioxidants; Blood Pressure; Lipid Peroxidation
