Low Density Lipoproteinemia in Obese and Type-2 Diabetics from Association of IR and LDLR

Authors: Gopalakrishnan Ramakrishnan, Puja Beriwal, Sangam and N. C. Chandra*

DOI: 10.23880/doij-16000194

Volume 4, Issue 1

Abstract

Universality of association of two receptors, LDLR (LDL receptor) and IR (insulin receptor), has been explored in various cell types and intracellular compartments including caveolae vesicles in plasma membrane. The existence of association of LDLR and IR has been proved in type-2 diabetes and diabetes associated obesity. The non-functionality of LDLR in conjugation with IR has been found as of a prime reason for developing LDL related atherosclerosis in insulin defunct system. Confocal microcopy and western blots are the major techniques used to explore this study.

Keywords: Insulin Receptor; LDL Receptor; Diabetes; Lipoproteinemia; Atherosclerosis

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