A Randomised Prospective Study Analysing the Effects of Lowering Serum Uric Acid in Chronic Kidney Disease (CKD) Progression and Cardiovascular Outcomes

Authors: Pursnani L* , Gupta A , Choudhary SS , Mahapatra H and Verma H

DOI: 10.23880/oajun-16000155

Volume 4, Issue 1

Abstract

Uric acid is an independent risk factor for the development and progression of kidney disease. In last two decades number of observational studies has examined the potential link between management of hyperuricemia with CKD progression, having conflicted results. Hence, this prospective, randomised controlled study was conducted among stage 3-5 CKD patients in patients to evaluate the effect of lowering uric acid levels in reduction of hypertension, and kidney disease progression and cardiovascular risk. Patients were randomized into two groups, one group (n=100) receiving allopurinol with a dose of 100-300 mg/day plus standard treatment and other group (n=50) receiving only standard treatment. Patients were followed at 3, 6 and 12 months of treatment. After 12 months of allopurinol treatment, serum uric acid levels were significantly (p

Keywords: Chronic kidney disease; Uric acid; Hypertension; Cardiovascular risk; Allopurinol treatment

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