Retrograde Synaptic Transmitter of Endocannabinoid System - A Neuromodulatory Pathway

Authors: Divya R, Ashok V and Rajajeyakumar M*

DOI: 10.23880/nnoaj-16000131

Volume 4, Issue 1

Abstract

Synaptic Neurotransmission & Retrograde Messengers: Neurotransmission across the Synapse is through the mechanism of release of neurotransmitters from the presynaptic junction, neurotransmitter that is released gets transported towards the postsynaptic terminal, where the receptors are situated. These neurotransmitters bind with the concerned receptors and activate them. Whereas in retrograde transmission, the signalling includes a diffusible messenger that is liberated from the postsynaptic element. This neurotransmitter travels "backwards" across the synaptic cleft, where it stimulates the presynaptic terminal receptors. The Receptors for retrograde messengers are generally present on or near the presynaptic nerve terminals, and their stimulation causes a modification in synaptic transmitter release. This type of retrograde neurotransmitters is involved in long-term synaptic plasticity and also has a significant role in the short-term regulation of synaptic transmission [1].

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