ISSN: 2577-4360
Authors: Akuru UB*, Amadi BA and Abbey BW
Breast cancer is an abnormal cell growth of the breast tissue and upon metastasis affects other organs of the body such as the liver, bones and lungs. The aim of this study is to investigate the effect of aqueous extract of Sorghum vulgare leafsheath, Eremomastax polysperma and Brillantaisia owariensis leaves on the liver, bone and kidney markers of 7,12- dimethylbenz[a]anthracene (DMBA) treated albino-rats. Sixty-three female albino rats weighing 120-250g, were used for the study for a period of 15 weeks. The animals were grouped into nine groups of seven animals each. Group I (control) was fed with normal feed. Groups II to IX, were orally administered 20mg DMBA/kg to induce breast cancer. Group II was untreated; Group III was treated with tamoxifen (6.6mg/kg). Groups IV- IX were treated with 500mg/kg Sorghum vulgare, 1000mg/kg Sorghum vulgare, 500mg/kg Eremomastax polysperma; 1000mg/kg Eremomastax polysperma, 500mg/kg Brillantaisia owariensis and 1000mg/kg Brillantaisia owariensis respectively. Treatment with the various extract showed significant decrease (p 0.05) of total bilirubin, calcium and urea concentration, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase activities when compared to DMBA-untreated group. Albumin concentration of the treated groups was significantly higher (p 0.05) than the DMBA-untreated animals. Gamma glutamyl transferase and acid phosphatase activities, uric acid, electrolytes and total protein concentration showed no significant difference (p 0.05) between the treated groups and the DMBA-induced animals. The present study demonstrates that the extract of the plants was able to reduce any burden posed on the liver by DMBA-induced breast cancer.
Keywords: Breast Cancer; Liver Function Test; Kidney Markers; Bone Markers DMBA
