ISSN: 2474-9214
Authors: Salauddin Al Azad* and Md. Iqbal Khan
Cancer is a malignant disease which is in most part incurable. It is not curable through normal medication. Different cure techniques have already equipped to wipe cancer out but still a mess that cancer finds its own way-out. Oncolytic viral therapy is a new promising strategy against cancer. Oncolytic viruses (OVs) can replicate in cancer cells but not in normal cells, leading to lysis of the tumor mass but are recognized by the immune system as pathogens and the consequent antiviral response could represent a big hurdle for OVs makes the concept compromised for cancer treatment or malignant metastasis. Every human cell has a hereditary program that upon enactment will cause cell demise, named apoptosis. Cancer cells can develop because of imbalanced expansion, cell cycle guideline and their apoptosis hardware: genomic mutant particles bringing about non-practical professional apoptotic proteins or over-articulation of against apoptotic sister proteins which structure the premise of tumor development. Shockingly, exercises gained from infections demonstrate that malignancy can't be viewed essentially as the inverse of apoptosis. Using anticancer genes as a therapy for cancer can be effective as they can go through the gene lines and make a call for destruction of malignancy. HAMLET (human α-lactalbumin made deadly to tumor cells) is such an anticancer gene which is found in human milk that can be effective in cancer treatment and also refusing new path making of cancer.
Keywords: HAMLET; Oncolytic Viruses; Apoptosis; P53; HDI; MAPK
