Characteristics and Micromorphology of Designed Regenerative a Cellular Dermal Collagen Particles Derived from a Combined Procedure of Supercritical Carbon Dioxide Fluids and Protease Treatments at Low Temperatures

Authors: Ching-Cheng Huang*, Guifeng Zhang, Meng-Jen Yang and Xiong xin Lei

DOI: 10.23880/aabsc-16000120

Volume 2, Issue 1

Abstract

A new regenerative collagen particle with extra-cellular matrix (ECM) was designed and prepared from porcine dermal. A specific tissue-cutting machine was designed to prepare extra thin tissue membranes, which could be used for preparing the regenerative collagen particles with ECM. Furthermore, a novel procedure combining supercritical carbon dioxide fluids technology and protease treatments at low temperatures was employed. Characteristics of the resulting regenerative collagen particles with ECM were observed by determining morphology, thermal property and mechanical property for clinic application of medical devices.

Keywords: Collagen; Morphology; Extra-cellular matrix; ECM

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