ISSN: 2578-4625
Authors: Silva Torres R*, Sequeda Juarez AA and Ramon Gallegos E
In Mexico, the use of plants has been traditionally used as an alternative treatment for various diseases, the Opuntia joconostle (xoconstle) has presented in several studies antioxidant activity, cytotoxic in cancer cells, hypoglycemic action and this because it is a very nutrient-rich fruit. The objective of this work was to evaluate the cytotoxic effect of the extract fraction of Opuntia joconostle on lung carcinoma cell line A459. The ethanolic extract of Opuntia joconostle was obtained by maceration, and then it was made preliminary phytochemical tests given positive for, alkaloids, coumarins, flavonoids, reducing sugars and phenolic compounds. Subsequently, the chemical compounds were separated by column chromatography and preparative thin layer chromatography, which fraction 8-14 was obtained. To evaluate the cytotoxic effect of the fraction on viability was evaluated in the A549 cell line. The results of the fraction presented diminishing of cell viability up to 99.9 % in lung carcinoma cells.
Keywords: Opuntia joconostle; Lung cancer; Mexican Medicinal Plants
