International Journal of Pharmacognosy & Chinese Medicine (IPCM)

ISSN: 2576-4772

Research Article

Synthesis and Anti Proliferative Activity of Thiosemicarbazone and 4-Thiazolidinones

Authors:
Notice: Undefined offset: 0 in /home/medwincom/public_html/article-description.php on line 436

Abstract

Thiosemicarbazone and 4-Thiazolidinones are heterocyclic compounds with a broad spectrum of biological activities such as anti-inflammatory, anti-viral, anti-bacterial, anti-fungal and anticancer. A series of ten derivatives of thiosemicarbazone and 4-thiazolidinones derivatives was synthesised and evaluated for their antiproliferative activity against human breast cancer cells (MCF-7). The structure of compounds was established by IR and 1HNMR spectral studies. The synthesized compounds possessed good to moderate anticancer activity using Adriamycin as a tandard. Out of ten synthesized compounds eight have GI50 value of

Keywords: Thiosemicarbazone; 4-Thiazolidinones; Human Breast Cancer Cells

View PDF

F1 europub scilit.net

Chat with us on WhatsApp

Welcome to Medwin Publishers. How can we help you today?