Synthesis and Anti Proliferative Activity of Thiosemicarbazone and 4-Thiazolidinones

Authors: Harpreet Kaur, Vivek Kumar Gupta and Monika Gupta*

Volume 3, Issue 3

Abstract

Thiosemicarbazone and 4-Thiazolidinones are heterocyclic compounds with a broad spectrum of biological activities such as anti-inflammatory, anti-viral, anti-bacterial, anti-fungal and anticancer. A series of ten derivatives of thiosemicarbazone and 4-thiazolidinones derivatives was synthesised and evaluated for their antiproliferative activity against human breast cancer cells (MCF-7). The structure of compounds was established by IR and 1HNMR spectral studies. The synthesized compounds possessed good to moderate anticancer activity using Adriamycin as a tandard. Out of ten synthesized compounds eight have GI50 value of <10 μg/ml demonstrating their potential activity. TGI for compound 6d was found to be comparable to Adriamycin (<10 μg/ml).

Keywords: Thiosemicarbazone; 4-Thiazolidinones; Human Breast Cancer Cells

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