ISSN: 2577-4360
Authors: Banger MG, Bhise M* and Khillare S
Objective: To study and compare biochemical parameter such as serum Lipid profile and alkaline phosphate in patients of carcinoma of breast with healthy normal controls. Methods: A cross sectional study was conducted in the Department of Biochemistry government medical college Nagpur with cooperation from surgery Department of the institute during period of May 2015 to October 2016. The study was approved by institutional Ethics Committee for research work. A total of 200 subjects were enrolled in this study, who were further divided into two groups of group A 100 subjects each between 25-75 years of age as histopathologically confirmed breast cancer cases and group B 100 subject of age, weight matched controls. Data was analyzed using unpaired t test. P< 0.05 was considered to be statistically significant and P < 0.001 was taken as statistically highly significant Results: Breast cancer of serum cholesterol, Serum triglycerides, serum HDL, serum LDL, serum VLDL level and serum Alkaline phosphatase 165.96±25.9 mg/dl, 115.54±27.73 mg/dl, 52.43±6.45mg/dl, 90.49±24.53mg/dl, 23.04+5.55mg/dl 73.16± 10.2 IU/L, as compared to mean of normal women 197.14±36.14 mg/dl 120.70±29.66 mg/dl 51.03±4.8 mg/dl 121.97±36.39 mg/dl 24.14+5.93 mg/dl 74.28±10.6 IU/L respectively Conclusion: The study showed that breast cancer patients had significantly higher levels of total cholesterol & LDLcholesterol while insignificant association was found in levels of HDL-cholesterol, VLDL-cholesterol & triglycerides between cases & controls. Serum ALP level didn‘t differ significantly.
Keywords: Breast Cancer; Lipid Profile; Alkaline Phosphate
