Anti-Allergic Studies of Albizzia Lebbeck and Syzygium Cumini (L- Syzygium Gambolana)

Authors: G V Balakrishna, Krishna Sowmya , Vijay Raj Bollapalli and MV Ragavendra Rao*

DOI: 10.23880/oajmb-16000103

Volume 1, Issue 1

Abstract

The anti-allergic effects of herbs Albizzialebbeck and Syzygium cumin were analyzed in wistar albino rats and Swiss albino mice, from the aqueous and methanol extracts of roots of these plants. Mast cell degranulation in rats was induced by clonidine and as a known factor d-disodium chromoglycolate administration and the extracts showed a significant reduction in mast cell degranulation, suggesting a possible antihistamine and anti-allergic actions. Clonidine induced catalepsy was reduced by a known chemical diphenhydramine. Clonidine induced catalepsy was also shown to be reduced to a lesser extent by the extracts. Milk induced Leukocytosis was reduced by Diazepam and it was compared with the extracts. Extracts also caused significant reduction in milk induced leukocytosis, but to a lesser extent than diazepam. Milk induced eosinophilia was reduced by Dexamethasone and it was compared with the extracts. Extracts also caused significant reduction in milk induced leukocytosis, but to a lesser extent than Dexamethasone. With these results it is indicated that roots of Albizzialebbeck and Syzygium cumin have anti-allergic effects.

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