Methotrexate in the Treatment of Generalized Pustular Psoriasis with Liver Involvement: A Case Report

Authors: Houshmand H, Nabavizadeh H, Houshmand G, Ghafouri Z, Alyasin S and Kouhsari E*

DOI: 10.23880/jidtm-16000128

Volume 3, Issue 1

Abstract

Generalized pustular psoriasis is a dangerous medical problem with abrupt onset. Here, we describe a ten-month-old girl with GPP. The girl presented small sized erythema and pustules on her cheek, which extended to her abdomen, upper and lower extremities. Skin biopsy was in favor of GPP. Despite negative microbial cultures and viral markers, laboratory data showed abnormal liver enzymes. After admission, she responded well to local emollient agents, antihistamine, systemic antibiotic and oral Methotrexate. Our report is special because despite increase in patient’s liver enzymes, Methotrexate, which is a liver complication potential drug, simultaneously improved general condition and liver enzymes.

Keywords: Seborrheic Dermatitis; Generalized Pustular Psoriasis; Methotrexate

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