Phosphine- and Isatin-Copper Complexes: Anticancer Activity, Mechanisms of Action and Structure-Activity Relationship Examples from the Last Ten Years

Authors: Vieira MA, Farias RL, Netto AVG and Nascimento-Junior NM*

DOI: 10.23880/macij-16000142

Volume 3, Issue 3

Abstract

Platinum-based metallodrugs candidates are extensively evaluated as antineoplastic agents against several tumoral cell lines, representing a considerable advance in cancer treatment. On the other hand, the hostile off-site toxicity has been limited their potential uses in clinical step. Thus, the search for novel active and selective antitumor drugs is a leading issue in the medicinal inorganic chemistry. As follow, the research focused on less toxic metals has strategic importance and several copper complexes have revealed promising activity. In addition, copper is an essential metal, which can increase the chances of reduced side effects. This review brings some copper complexes that showed highlighted anticancer activity as drug prototypes from the last ten years (2010-2019), involving phosphine and isatin ligands, different redox states, modes of action and the study of structure-activity relationship (SAR).

Keywords: Copper Complexes; Anticancer Activity; Phosphine; Isatin; Structure-Activity Relationship

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