Intervene of EBV and HCMV in Relation to p27 and p73-Cell Regulatory Proteins in Histopathological Changes of Sinonasal and Nasopharyngeal Carcinomas

Authors: Ali JassimMM, Mahmood MM* and Mohammed Ali SH

Volume 3, Issue 3

Abstract

Background: Sinonasal and Nasopharyngeal carcinomas are related to many environmental, genetic predisposing and viral infections. Many studies have implicated EBV in the progression of benign and malignant head and neck tumors by affecting cell cycle proteins expression. The p73 and p27 were implicated in carcinogenesis of nasopharyngeal and sinonasal carcinomas. Objective: The research aimed to evaluate the impact of EBV and HCMV in relation to cellular protein expressions of p27 and p73-cell cycle regulatory genes on histopathological alterations of sinonasal and nasopharyngeal carcinomas. Patients and Methods: Eighty three formalin fixed, paraffin embedded tissue blocks belong to 65 nasopharyngeal (NPC) and 18 sinonasal carcinomas (SNC) were investigated for EBV, HCMV, P73, P27 coexistences. Results: The highest positivity percentage (50%) of EBV in SNC was seen in moderately differentiated group. While in NPC tissues the highest level (74.5%) of HCMV was detected in undifferentiated group. The highest positivity percentage (47.1%) of p73 in SNC group was in moderate differentiated grade, while the highest positive-p27 percentage in NPC group was in undifferentiated grade (76.3%).

Keywords: NPC: Nasopharyngeal Carcinoma; SNC: Sinonasal Carcinoma; HCMV: Human Cytomegalovirus; CISH: Chromogenic in Situ Hybridization; IHC: Immunohistochemical

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