ISSN: 2691-5782
Authors: Qureshi S*
Reversible posterior encephalopathy syndrome is a clinic radiologic entity characterized by headaches, altered mental status, seizures, and visual loss and is associated with white matter vasogenic edema predominantly affecting the posterior occipital and parietal lobes of the brain. We herein, present a rare complication of mixed connective tissue disease. A 12-year old boy presented with generalized tonic clonic fits, aphasia, fever and generalized body swelling since 2 weeks. His labs showed hypercholestremia, hypoalbuminemia and massive proteinuria. Renal biopsy revealed secondary membranous glomerulopathyand and he developed posterior reversible encephalopathy syndrome. His anti RNP and anti-smooth muscle came back positive. Evaluation by magnetic resonance scan of the brain showed that the child had hyper intense signal in the parieto-occipital regions. All signs of PRES started resolving after seven days of supportive treatment evidenced by subsequent radiological evaluation. PRES and secondary membranous glomerulopathyshould be kept in mind in any connective tissue disease that is on prolonged immunosuppressive therapy.
Keywords: Posterior Reversible Encephalopathy Syndrome; Membranous Glomerulopathy; Mixed Connective Tissue Disease
