ISSN: 2691-5782
Authors: Gharib AF*, Althobaity AS, ALnemari SH, Alharthy RS, Aljohany RS, Alsufyani RM, Hagag HM, Khalifa M, Khamis AA and Ismail KA
Background: Psoriasis is a chronic autoimmune condition characterized by infiltration of keratinocytes by inflammatory cells that cause scaling on the skin surface. Psoriasis is considered now as T cell-mediated disease. INF- γ is considered a key cytokine in the pathogenesis of psoriasis. Objectives: To evaluate the level of IFN gamma in order to recognize its role in the pathogenesis of psoriasis and its relation to the severity of the disease. Materials and Methods: We investigated the level of serum IFN-γ in 40 patients with psoriasis and in 25 healthy controls by ELISA Kit. We used the PASI score to assess the severity of psoriasis. Results: The serum levels of IFN-γ were elevated in all patients with psoriasis but not in all healthy controls. Also, the serum levels of IFN-γ were correlated with the severity of disease in psoriatic patients. Conclusion: The level of IFN-γ can be used as a useful estimate of the severity of the disease and may be used in daily practice as prognostic follow-up marker.
Keywords: Psoriasis; IFN-γ; PASI score
