ISSN: 2577-4328
Authors: Morales Y*, Uzcatequi OE, Duran A, Montero Y, Pozo L, Martucci D and Jimenez W
Acute dermal toxicity is the adverse effect that occurs within a short period of 24 hours after exposure. The test provides basic information to classify and label the products, being an initial step for other more lasting exposure studies. The Test Substance is a solution composed of 24% Hydrofluoric Acid (HF), controlled with the additive GQ-300®, which is a strongly acidic chemical composition and safe for human use, obtained by mixing strong acids with the purpose of achieving a balanced mixture of acids which allows, through additivation, the control and safe handling of other strong and corrosive acids. The objective of this study is to know the effect and absorption by the cutaneous route that this mixture has, for which it is used with a fixed volume of three labeled solutions and of different concentrations of HF, administered in Female Rats BIUO: Wistar in young age, adult rats and female mice BIOU: NMRI in young adult age. In conclusion the solutions of HF Controlled with Gq-300® Additive. They cause skin irritation and the degree of irritation will depend on the type of skin, being in the most sensitive and young skin, where the irritation damage and the necrosis caused by regeneration of it will be more pronounced in a short period of time. The Controlled Fluorhydric Acid with the additive GQ-300, could provide the safest handling that the 48% pure Hydrofluoric Acid (HF), which today does not have, besides allowing a reversible effect, in case of an accident, which does not offer the pure HF of 48%.
Keywords: Dermic Toxicity; Hydrofluoric Acid; Additives; Azeotropic Mixture
