Beta-Lactamases and ESBL

Authors: Abdelmoktader A* and El Far AT

Volume 3, Issue 4

Abstract

Microbial resistance through extended-spectrum β-lactamase (ESBL) was first reported in the early 1980s in Europe and subsequently in the United States soon after the introduction of third-generation cephalosporins in clinical practice. β -Lactamases are enzymes that inactivate β -lactam antibiotics by opening the β-lactam ring of penicillins and cephalosporin and abolish their antimicrobial activity. Beta-lactamases have been described for many species of grampositive and gram-negative bacteria. Some β-lactamases are plasmid mediated while others are chromosomally mediated.

Keywords: Esbl-Î’ -Lactamases-Tem; Shv; Ctx-M; Toho; Oxa; Per; Veb-1; Bes-1 Beta Lactamases

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