ISSN: 2578-4625
Authors: Ngatali CFS*, Boumba LMA, Okouango BJC, Mabiala Y, Eouani LM, Moukassa D and Nkoua Mbon JB
Objective: To determine molecular profile of breast cancer in Pointe Noire. Patients and Methods: We conducted a cross-sectional study covering the period of January 2018 to September 2019, one (1) year and nine (09) months in the General Hospital of Pointe-Noire. 48 records of patients who were diagnosed with breast cancer with or not immunohistochemistry results at Loandjili General hospital. The variables studied were: Age; the family breast cancer history; tumor localization, histological type, estrogen receptors status, progesterone receptors status; HER2 receptors expression, and molecular profile. The comparison of the qualitative variables was made by the chi2 test and the comparison of the quantitative variables was made by the student test (t-test). The p-values were calculated with the data comparison program that uses chi2 tests (Pearson and Fischer) and t-test. Results were statistically significant for P˂0.05. Results: The average age was 45.7 years with extremes of 22 and 79 years. Two women had a history of breast cancer. Breast cancer was more located in right in 46 % of cases. Ductal invasive carcinoma was the most represented histologic type in 73 %. The histopronostic grade II of Scarff bloom Richardson (SBR) was the most represented in 47.5% of cases. 65% of the estrogen receptors were negative. Negative progesterone receptors were the most represented in 53% of cases. Negative expression of the HER2 were the most represented in 62 % of cases. The molecular profile Luminal A were the le most represented molecular profile accounted for 45. In our study, we noted a prevalence of the age group of 40 to 49 years of 25% of which 15% of Luminal A was also observed. There was not relationship between age and molecur profile (P˃ 0.05). A relationship was noted between molecular profile and histological grade (p ˂0.05). Conclusion: Breast cancer is a real public health problem worldwide. It is the first cancer and the leading cause of cancer death in women worldwide. In Pointe Noire the molecular profile is dominated by Luminal A. This study is important and help to the best therapeutic choice of breast cancer.
Keywords: Molecular Profile; Breast Cancer; Pointe Noire
