ISSN: 2574-7800
Authors: Pektas SD*, Edgunlu TG and Sevim KC
Background: Psoriasis is a chronic, inflammatory and proliferative skin disease, which is associated with comorbidity such as cardiovascular disease and insuline resistance. Vascular alterations observed in psoriatic lesions are now considered to be an important feature of the disease. Netrin-1 is a laminin-related molecule and expressed in tissues such as spinal cord, pancreas, mammary gland, or lung. Netrin-1 has been shown to act as a chemoattractant or chemorepulsive cue for many migrating axons and neurons. The present data published either suggest an antiangiogenic role or a proangiogenic role for netrin-1. A recent study also argues for a role of netrin-1 in autoimmune diseases and in the inflammatory reactions associated to these diseases. Objective: We aimed to investigate netrin-1 levels in psoriasis patients and its possible relation with duration and severity of disease. Methods: A total of 40 patients and 40 controls were included in this cross-sectional study, and disease severity was evaluated according to psoriasis area severity index (PASI) scoring. Demographic data, clinical features, anthropometric measures and laboratory findings were recorded in all study subjects. Serum netrin-1 levels were measeured using ELISA kit. Results: Psoriasis patients had lower values for netrin-1 compared to the control group. But, there were no statistically significant differences in netrin-1 levels between psoriasis patients with PASI>10 and with PASI≤10. Psoriasis patients with PASI>10 had significantly higher PASI, CRP, WBC and RDW values than psoriasis patients with PASI≤10. We founded that psoriasis patients had netrin was negatively correlated with BMI, duration of disease, PASI and CRP. Conclusion: Our data shown that there may be a relationship between psoriasis and reduced netrin-1 level. It has been suggested that this relationship may have arisen with chronic inflammation, long disease duration, disease severity and angiogenesis.
Keywords: Psoriasis; Netrin-1; Inflammation; Angiogenesis
