Proteomics: Applications in Disease Diagnosis to Develop Precision Medicine

Authors: Kavita Vasdev* and Sonali Sengupta

DOI: 10.23880/bpoj-16000129

Volume 4, Issue 1

Abstract

Proteomics is a systems biology science that studies not only the protein components of a cell but also the interactions between them. Proteomics is a powerful tool to study disease progression at an individual level and its ability to provide information for diagnosis and therapy tailored to the individual manifestation of the disease is unlimited. It encompasses wet laboratory experiments such as 2-D gel electrophoresis and mass spectrometric techniques, but also computational analysis of biological data which include software such as GO, Cytoscape etc. The present review aims at studying the applications of proteomics in the diagnosis, Prognosis of disease progression during therapeutic intervention, and identifying therapeutic targets of the diseases, specifically neurodegenerative diseases like Alzheimer’s, Parkinson’s, Cardiovascular disease as Myocardial Infarction and systemic disease like Cancer- in order to develop precision medicine for applied personalized therapy

Keywords: Proteomics; 2-D Gel Electrophoresis; MS-Mass Spectrometry; Protein-Protein Interaction

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