ISSN: 2574-187X
Authors: Valyaev A
Extensive research of biomaterials at nanoscale has led to development of novel medical technologies including prosthetic devices and new surgical materials and methods. In many cases, however, biomechanical properties and health impacts of nanomaterials are poorly understood. Here we present three key innovations used in treatment of severe bone injuries among veterans and athletes: (i) Prof. Ilizarov’s apparatus, (ii) ‘Perftorun’, known as ‘blue blood’ therapy discovered by Prof. Beloyartsev in Russia, (iii) ‘Litar’, an artificial bone technology invented by Prof. Krasnov that is used to replace bones defects. Prof. Petrov, coauthor of our article, has his own rich experience in implementation of novel technologies for health protection and safety, used to treat injured military personnel in Russian armed conflicts, such as Chechen war. The FDA (U.S. Food and Drug Administration) has even established a separate group within the Agency to develop better knowledge of interactions of nanomaterials with biological systems, and to assess the adequacy of testing approaches for evaluating safety, effectiveness, and quality of products, containing nanomaterials. Further we present our analysis of key challenges that hinder commercialization of new biomedical technologies and limit its using in human patients. By way of example, we will illustrate how suboptimal regulatory approval process for new biomedical devices can substantially increase the time and cost of technology translation from bench to bedside and discuss the importance of technology’s patent protection in attracting private investment required for commercialization of biomedical technologies. Lastly, using the three above-mentioned innovations as our case studies, we will suggest approaches for improving the outcomes of biomedical technology translation. Some our new achievements, connected with advanced materials, such as bio and medical ceramics, that today used in implant dentistry in Russia is under consideration: use of biochemical markers of ostaclenogenesis in dental implantation and directional bone metabolism and regeneration. Glucocorticoid-induced osteoporosis; osteoprotegerin therapy; arthritis; oncological diseases.
Keywords: Biological Systems Biomedical Medicine; Nanomaterials Technologies; Prosthetic Devices; Commercialization
