An Update on Management of Diabetic Neuropathy with Diabetic Foot Syndrome-Optimization of Therapy Cost Effectively with Avoidance of Gangrene and Amputation-A Systematic Review

Authors: Kulvinder Kochar Kaur*, Allahbadia G and Mandeep Singh

DOI: 10.23880/oaje-16000145

Volume 4, Issue 1

Abstract

Earlier we have reviewed obesity and diabesity etiopathophysiology (both type1 and type2 diabetes mellitus (T2DM)) and suggested best methods of classification of T2DM from effective management point of view utilizing weight neutral anti diabetics, besides importance of empagliflozin a SGLT2 inhibitor in T2DM both with the idea of starting combination therapy for T2DM as well as for cardiovascular outcome trials point of view and emphasized on role of natural plant based therapies for better treatment of diabetes. Here we present a systematic review regarding better management of neuropathic pain accompanying T2DM along with best optimization, methods for treating diabetic foot ulcer (DFU). In view of complex etiology of DFU due to, multifactorial nature with importance of polyneuropathy we further highlight the role of neutrophil extracellular traps (NET) and how utilization of deoxyribonuclease might escalate wound healing besides roles of ozone and different kinds of dressings, role of recombinant human epidermal growth factor gel, and sucrose octa sulfate and other dressings besides importance of micronutrient deficiencies role of vitamin D, and importance of therapeutic footwear individualization and multidisciplinary team management in prevention of amputations and management of DFU cost effectively.

Keywords: T2DM; Neuropathic Pain; Diabetic Foot Ulcers (DFU); NET; Deoxyribonuclease; Recombinant Human Epidermal Growth Factor Gel; Sucrose Octa Sulfate Dressing; Therapeutic Footwear; Vitamin D; Ozone

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