Investigation of In Vitro Cytotoxic Effects of Flumethrin by Using Brine Shrimp Lethality Assay

Authors: Ufuk Mercan Yücel*

DOI: 10.23880/apct-16000174

Volume 5, Issue 1

Abstract

Flumethrin is a synthetic insecticide, a type II pyrethroid derivative group derived structurally from naturally occurring pyrethrins in some plants. It is widely used in veterinary medicine, public health and agricultural struggle. It is commonly used in cattle and sheep for the treatment and control of infestations due to biting flies, sucking and stinging lice, ticks, scabies and other external parasites. It is used in the treatment of scabies infections in dogs. It is also frequently used in the control of Varroa disease in beehives. According to the World Health Organization (WHO) classification, flumethrin has class II toxicity (moderately hazardous). The acute oral LC50 value of flumethrin was 41-3849 mg/kg in female Wistar mice. Flumethrin is toxic to fish and aquatic animals. It has been reported that flumethrin is also toxic to honey bees, causing behavioral disorders and nerve damage, shortening hive performance and life span. 

Keywords: Flumethrin; Brine Shrimp Lethality Assay; Artemia Salina; Cytotoxic Effect

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