ISSN: 2689-8020
Authors: Abboud FZ*, Bouziane A, Youssoufi MA, Bouhafa T and Hassouni K
Introduction: Soft tissue sarcomas (STS) are malignant tumors of mesenchymal origin that originate in any connective tissue or body support tissue. They represent 1% of all adult malignancies and are much less common than benign tumors developed in the soft tissue. Objective: The objective of the study is to analyze the factors influencing the prognosis of soft tissue sarcomas. Materiel and Methods: This is a retrospective cohort study of 50 cases of soft tissue sarcomas over a period of 05 years. The average age of the patients is 50 years, with a sex ratio of 01. The average consultation time is 22 months following the auto palpation of a mass gradually increasing in size. The MRI was performed on 37 patients or 74%. Surgical biopsy was performed on 75% of our patients. The predominant histological type was synovialosarcoma in 32% of cases, followed by lympsarcoma which accounted for 28% of cases. High grades (II and III) are the most common and accounted for 50%. Margins of exeresis were R0 in 12% of cases, R1 in 24%, R2 in 8% and unspecified in the rest. 56% of patients underwent conservative surgery, 20% underwent radical surgery and 24% were not operated on due to the stage of the disease. Results: The evolution shows 30% of local recurrences revealed on MRI and 26% of metastases, mainly pulmonary metastases. The adverse prognostic factors for local recidivism were as follows: tumor size >10 cm, the depth of the tumor, the histological grade, margin status, failure to administer adjuvant radiotherapy. Unlike local control, which was affected by many factors, metastatic recurrence was determined by only four independent factors: the depth of the tumor relative to the fascia; the size of the tumor, the grade of the tumor, and the histopathology. Conclusion: The improvement of patients’ quality of life, and therefore their prognosis, depends firstly on treatment from the outset in order to reduce the risk of local recurrence and iterative surgery, and secondly on increasingly functional surgery, hence the importance of multidisciplinary management in a specialised environment.
Keywords: Sarcomas; Soft tissue; Prognostic factors
