ISSN: 2640-2653
Authors: Amini M, Rahmati H, Tanhaei S and Pournajafi A*
Background and Aim: Pseudomonas aeruginosa is one of the most important pathogenic bacteria causing nosocomial infections that is inherently resistant to many antibiotics. Therefore, the present study was performed to investigate the susceptibility and antibiotic resistance patterns of ESBL-producing P. aeruginosa strains isolated from patients referred to Zanjan hospitals. Materials and Methods: In this descriptive-analytical study of the study of 300 cases of urinary tract infection in Zanjan medical centers in 2019, 100 isolates of P. aeruginosa were identified by standard bacteriological methods. Antibiotic susceptibility of the isolates was determined by disk diffusion method and ESBL-producing isolates were identified by combined disk method. Results: The most resistant to ampicillin (75%) and tetracycline (48%) were the most sensitive to amikacin (90%) and nitrofurantoin (87%), respectively. A total of 49 samples were identified as the final ESBL producer. Conclusion: Given the high percentage of resistance to third generation cephalosporins, careful antibiograms and avoidance of overuse of antibiotics in infections caused by ESBL-producing organisms is an inevitable necessity.
Keywords: Extended-Spectrum Beta-Lactamases; P. aeruginosa; Urinary Tract Infection; Antibiotic Resistance
