ISSN: 2639-2534
Authors: Surbhi V Upadhyay, Raksha V Zala and Keyur D Bhatt*
Novel benzothiazole Schiff bases namely N-(4-chlorobenzylidene)-4,6-difluorobenzothiazole-2-amine; 4,6-difluoro-N-(4- nitrobenzylidene)benzothiazol-2-amine and N-((1H-indol-3-yl)methylene)-4,6-difluorobenzothiazole-2-amine have been synthesized from condensation reaction of 4,6-difluoro-2-amino benzothiazole with different aromatic aldehydes like 4-chlorobenzaldehyde, 4-nitrobenzaldehyde and 1H-indole-3-cardaldehyde. The structures of all the compounds were characterized by elemental analysis, FT-IR, Mass and 1H-NMR spectroscopy. Schiff bases have been screened for antimicrobial activity against bacteria and fungi by using MIC determination. In vitro antibacterial and antifungal activity of ligands were assayed against gram positive (S. Aureus, B.Subtilis), gram negative bacteria (S. Marcescens, E. coli) and Rhizopus sp. and A. Niger. The standard drugs ketoconazole and ciprofloxacin were used to screen antimicrobial activity.
Keywords: Schiff Base; 4,6-difluoro-2-aminobenzothiazole; Antibacterial Activity; Antifungal Activity; MIC determination
