ISSN: 2640-236X
Authors: Jui-Yu Lin and Chuan-Yuan Lin*
Injectable poly-D,L-lactic acid (PDLLA) is a biocompatible, biodegradable, and biostimulatory substance that is used as a new soft tissue filler. This article discusses the cases of three patients who received facial injectable PDLLA administration. It also provides an overview of PDLLA microsphere studies and adverse events of injectable PDLLA. Animal studies have identified hybrid tissue formation inside polymeric microspheres. Clinical studies on PDLLA injection with long-term follow-up in nasolabial fold correction and penis shaft augmentation have demonstrated its efficacy and safety. In 2014, injectable PDLLA was first approved by the Korean Food and Drug Administration for facial cosmetic applications. From April 2014 to July 2018, approximately 16,000 patients received facial PDLLA filler injections in Korea. No severe adverse effects apart from one infection and five nodule formations were reported. We also compared injectable PDLLA with its identical form, i.e, injectable poly-L-lactic acid (PLLA). PDLLA microspheres differ from those of PLLA in microparticle morphology, reconstitution time and water volume, needle clogging rate, nodule formation rate, collagen formation pattern, and longevity. Injectable PDLLA possesses all the features of ideal filler. However, further studies are required to better understand injectable PDLLA.
Keywords: AestheFill; PDLLA; PLLA; Microspheres; Biostimulatory; Filler
