ISSN: 2474-9214
Authors: Ibrahim Arman*
Bezafibrate, an antilipemic agent has important effects on fatty acid metabolism and insulin sensitivity. Researches are very interested to study Drug-DNA interactions because DNA is an important material in maintaining cell life. In this research, DNA and protein binding activity of bezafibrate was studied by UV absorption titration and molecular docking method. In addition, the effect of the drug on Escherichia coli as a human intestinal flora bacterial strain was examined using Broth Dilution method and Agar Disc Diffusion method. In this research. Docking study showed that bezafibrate made 3 hydrogenic bonds and some hydrophobic bonds with the minor groove of double-helix DNA and with colchicine binding site between α-tubulin and β-tubulin. Bezafibrate showed no effect on the growth of the bacterial strain not only in the dilution method but also in the agar disc diffusion method.
Keywords: Docking; Dna; Flora; Bezafibrate; Tubulin; Genotoxic
