Effect of Nsukka Red Palm Oil on Haematological Parameters of Paracetamol Treated Albino Wister Rats

Authors: Obeta MU* , Olaniru BO , Ocholi MI , Etukudoh NS , Dawud AF , Iheanacho CU , Ugwu BK and Ntuhun BD

DOI: 10.23880/fsnt-16000219

Volume 5, Issue 3

Abstract

Nsukka palm oil (red palm oil -RPO) has been described as one of the best RPO in Nigeria. It has been the most expensive RPO among others. RPO has an antioxidant activity. Paracetamol equally has been one of the most commonly used analgesic and antipyretic drug that has been highly abused because of self-medication among Nigerians. The study was aimed at discovering the RPO effect on the toxicity of paracetamol in haematological parameters. Twenty albino Wister rats, divided into four groups of five rats each were used in this study, the first group was the control group while the rest group were the experimental groups, group 3 and 4 were pretreated with 1ml and 2ml red palm oil respectively, however on the fifth day 3g/kg body weight of oral paracetamol was given to group 2, 3 and 4. Haematological parameters - red blood cell count, white blood cell count and white cells differential count were also assayed using routine methods. The group with 1ml RPO showed significance (5.10±0.04) P

Keywords: Nsukka; Red Palm Oil; Haematological Parameters; Paracetamol; Albino Rats

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