ISSN: 2577-4360
Authors: Agarwal SK* and Singh S
Protein folding is a single most important process in biology whose complexity within living cell has been appreciated. Any deviation from the predetermined folding pathways might lead to the formation of ‘non-native’ conformations. Furthermore, mutations cause misfolded, non-functional form of proteins to accumulate. In spite of the tremendous progress made in the area of protein engineering, we can not reliably predict structural motifs in proteins from their amino acid sequence alone. Thus the real challenge is to work out the guidelines that might enable to predict how a protein would fold.
Keywords: Protein folding; Protein misfolding; Factors; Nucleation; Consequences
