Synthesis and Anticancer Evaluation of Novel Nicotinamide Derivatives Containing Sugars

Authors: Hamoud MMS, Ghanim AM, Osman NA, Hassan AEA, Abdel-Fattah HA and Sebaiy MM*

DOI: 10.23880/macij-16000159

Volume 4, Issue 2

Abstract

A series of nicotinamide derivatives tailed with monosaccharides via hydrazones linkage have been synthesized and evaluated for their anticancer activity against the NCI tumor panel. These conjugates were synthesized by acid catalyzed condensation of N-(4-(hydrazinecarbonyl) phenyl) nicotinamide with corresponding monosaccharides. The newly synthesized compounds were characterized by 1H-NMR, 13C-NMR, IR and elemental analysis. Weak anticancer activity was observed against the NCI 60 cell line screening.

Keywords: Nicotinamide; Monosaccharides; Anticancer; Hydrazones; NCI 60 cell line

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