New Understanding of BBB Impairments in Ageing and Neurodegenerative Diseases

Authors: Xin Y*

Volume 3, Issue 1

Abstract

Ageing is the major risk factor for neurodegenerative disorders such as Alzheimer’s disease (AD). The impairments of the blood-brain barrier (BBB) have been frequently reported in numerous neurodegenerative diseases and may serve as an early marker of AD and dementia. Recently, new investigations have demonstrated that impairments of BBB during normal ageing is not simply breakage or leakage of the structure, but gradually loss of transcytosis and pericytes. Such interesting results are calling further investigations on the transportation capabilities of BBB and other barriers such as blood and cerebrospinal fluid barriers, refreshing our exploration of AD therapeutics, and may lead new drug delivery method.

Keywords: Blood-brain barrier; Alzheimer’s disease; Transcytosis; Pericytes

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