Evaluation of the Immunomodulatory Activity of the Methanol- Methylene Chloride Extract of Parkia Biglobosa Jacq Benth. (Fabaceae) Stem Bark in Mice

Authors: Peter IE , Nwabunike IA , Onwuka AM , Mbaoji FN and Obi BC

DOI: 10.23880/vij-16000246

Volume 4, Issue 2

Abstract

The study was carried out to assess the effect of methanol/methylene chloride extract (MME) of Parkia biglobosa stem bark on specific and non-specific immune responses in rodents. Adult Swiss albino mice (20-35 g) of either sex were divided into five groups (n=5) and treated for 10 days. The effect of MME on adaptive immunity was evaluated using neutrophil adhesion test and cyclophosphamide-induced neutropenia while mice lethality test was used to evaluate its effect on non-specific immunity. Results of the neutrophil adhesion test showed a significant (P

Keywords: Immunomodulatory Activity; Methanol-Methylene Chloride; Saponins; Terpenoids

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