Recent Advances and Developments in Cochleate Technology

Authors:

Shuddhodana¹, Nagarsekar K² and Judeh ZMA^1*

DOI: 10.23880/nnoa-16000119

Volume 2, Issue 2

Abstract

Cochleates are lipid based cylindrical solid particulates formed by rolling of large continuous bilayer sheets. They are promising drug delivery vehicles with sustained release capabilities and show improved bioavailability, efficacy as well as reduced toxicity of encapsulated drugs. They are known to be extremely stable and hence enhance the quality of drug formulation by increasing the shelf-life of the formulation. Their nano- to sub-micrometer size range allows for delivery through various routes of administration. This review highlights recent advancements in cochleate technology with respect to their composition, self-assembly, formulation and a brief account of existing applications.

Keywords:

Cochleates; Nanocochleates; Drug delivery; Lipid particles; Liposomes

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