ISSN: 2577-4360
Authors: Balmasova IP, Arutyunov SD, Tsarev VN and Unanyan KG
This review article summarizes current knowledge on the association between lipid metabolism and periodontal diseases as well as the role of lipids in the realization of the etiologic and metabolic role of periodontogenic bacteria in this process. Extremely high prevalence of infectious inflammatory periodontal diseases and their currently established impact on the development of systemic conditions is a prerequisite for this paper. The role of lipids as an important factor of the vital activity of micro- and macroorganisms is much addressed in published sources. However, a systemic approach (in particular, in clinical stomatology) is yet to be fully established. Meanwhile, the advances in molecular biology allow for better understanding of the mechanisms of lipid involvement in the development of the virulent properties of periodontogenic bacteria, the modulating the process of bioadgesis of these bacteria to the solid tissues of the oral cavity, their influence on the composition and ultrastructure of the original biofilm of the oral cavity, the specificity of the interaction between periodontitis causative agents and host cells, the regulation of inflammatory and immune processes, pathogenically relevant bone tissue resorption, and the development of systemic effects. As a result, this knowledge may be potentially applied for designing the innovative approaches to the evaluation of the diagnostic markers of pathological periodontal tissues, the treatment and prevention of periodontal diseases.
Keywords: Lipid metabolism; Periodontal disease; Periodontogenic bacteria; Systemic effects
