COVID-19-Associated Liver Injury Is a Key Determinant of Patient’s Survival in a Low Endemicity Area from Central Italy

Authors: Ilaria L , Andrea A , Vincenzo M , Marco I , Elisabetta T , Andrea Di L , Loredana S , Mario A and Massimo A

DOI: 10.23880/ghij-16000174

Volume 5, Issue 2

Abstract

1.1. Background: Liver injury (LI) occurring in patients with COVID-19 has been reported, yet its prognostic significance remains unexplored. 1.2. Aim: To investigate whether the onset, type and severity of virus-associated LI predicts the clinical outcomes of the disease 1.3. Methods: All consecutive patients with COVID-19 admitted to the Infectious Disease Unit of the University Hospital of Rome “Tor Vergata” from February to May 2020, were enrolled. LI was defined as the presence of an elevation of aminotransferases, gamma-glutamyl transferase or alkaline phosphatase greater than 1.5 times above the upper limit of normality (ULN), and/or a total bilirubin greater than 2.0 mg/dl. Death was considered as the primary endpoint. 1.4. Results: Among 151 hospitalized patients (mean age, 64 ± 18 years; 62.9% males) 41 (27.1%) died. LI was found in 57.6% of cases and in 23.8% was already present at admission. LI was associated with older age (p=0.006), longer hospital stay (p

Keywords: SARS-Cov-2; COVID-19; Liver Injury; Survival

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