ISSN: 2573-1734
Authors: Priyanka Verma*
Coronavirus are pathogens that have severe effects on animal and human health. These are mostly responsible for respiratory and enteric ailments that can be dangerous for human wellbeing. For instance, these have been observed as a cause of Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) among people of all ages. However, irrespective of the knowledge about the severity of the conditions caused by outbreak of coronaviruses on human health and its subsequent monetary and cultural effects, the alternatives for its prevention and treatment remain restricted. This is what makes it important to enhance our knowledge regarding the spread and replication of the infection and their communication with the host. When compared with other +RNA infections, coronaviruses possess huge genome and make use of an intricate genome expression strategy. A large number of coronavirus proteins found in the infected cell is another factor after virus assembly and replication that leads to coronavirus host transmission. For example, these proteins associate with the host cells and make an ideal environment for the replication of coronavirus. They actually alter the host gene expression or counteract the antiviral defences of the host. These coronavirus–host interactions play a major role in the viral pathogenesis and will be the determining factor for the infections that result in the disease. It is because of the complexity of the proteome and the replication cycle associated with the coronavirus, that our knowledge regarding the host factors associated with coronavirus replication is still in its initial stages when compared to other +RNA viruses. Here is the summary of the current understanding linked with of coronavirus–host interactions at the infected cell level with special attention for the assembly and function of the viral RNA-synthesising machinery and the avoidance of cellular innate immune responses.
Keywords: COVID 19; (SARS-CoV-2)
