The Muddle of Immune Response in Coronavirus Disease-19

Authors: Vyas AK*, Garg G and Gupta P

DOI: 10.23880/oajmb-16000171

Volume 5, Issue 3

Abstract

Coronavirus Disease-19 (COVID19) caused by the enormously spreadable SARS- CoV-2 virus has appeared as a global pandemic and leads to high mortalities. Approximately 31,243,339 people have been infected so far with this disease which has led to the death of more than 965,103patients as of 21st Sept 2020. There are many drug molecules under-trials are in phase I and II. The numerous possible candidates for vaccine development against this infectious virus are also in the pipeline. Although, so far no molecule as a therapeutics or vaccine for prevention has been approved. Recent reports have observed that severely ill patients have a differential immunological profile compared to mild COVID-19 infection. Current studies globally observed that the cytokine storm maybe leads to the severity of COVID19 infection. In this article, our focus is to describe the present knowledge and status of differential immune profile among patients infected with COVID19 infection and their association with disease progression mild to severe.

Keywords: Coronavirus Disease-19; T and B cells; Monocytes; Macrophages and Neutrophils

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