Replacing Methotrexate with Letrozole in Cases of Early Ectopic Pregnancy as an Innovative Therapy - A Short Communication

Authors: Kulvinder Kochar Kaur*, Allahbadia GN and Singh M

DOI: 10.23880/oajg-16000202

Volume 5, Issue 1

Abstract

In cases of early ectopic pregnancy the only medical therapy advocated till now has been single or multiple dose methotrexates with some preconditions. Here the role of an aromatase inhibitor, letrozole is discussed as a novel drug that possibly can be considered for replacement of methotrexate in view of its simplicity of use, cheap, relatively free of side effects associated with methotrexate, not having many contraindications other than the haemodynamic stability, size of mass, ruptured ectopic pregnancy. Currently letrozole is being utilized commonly for the treatment of hormone sensitive breast cancer, besides as a drug for ovulation induction in cases of poly cystic ovarian syndrome (PCOS). Only more randomized controlled trials (RCTs) are needed before one can safely utilize it in routine clinical practice without fear of any haematological side effects of methotrexate.

Keywords: Early Ectopic Pregnancy; Medical Therapy; Methotrexate; Letrozole

View PDF