ISSN: 2574-7800
Authors: Stephanie P*, Saturno B and Rosanelly R
Drug reaction with eosinophilia and systemic symptoms syndrome (DRESS) is a pharmacological hypersensitivity reaction, most frequently associated with antiepileptic drugs and sulfonamides, characterized by skin rash, fever, lymphadenopathy, facial edema, hematological alterations and visceral organ involvement, which generally present within 8 weeks from the beginning of treatment. The mortality rate is 10-20% and liver failure represents the main cause of death in these patients. We report a case of a 24-year-old female patient with a history of inflammatory acne under treatment with trimethoprim sulfamethoxazole (tab 800/160 mg every 12 hours) who presented, on her third week of treatment, a skin rash, fever, facial edema, lymphadenopathy, eosinophilia and liver failure. The drug was discontinued and treatment with intravenous hydrocortisone at a therapeutic dose was started, observing a decrease in liver enzymes after 4 days of treatment, with a good outcome.
Keywords: DRESS; Drug; Trimethoprim sulfamethoxazole
