ISSN: 2577-4379
Authors: Srivastava V, Agarwal SP, Singh Kalra SJ Trivedi N and Dubey A*
Remodeling mechanism analysis of three HIV enzymes based on computational analysis for potential active sites identification of three viral enzymes, reverse transcriptase (RT), integrase (IN), and protease (PR) are all good drug targets and three distinct types of inhibitors, which block the polymerase activity of RT and IN, have been approved to treat HIV-1 infections, A better understanding of the structure and function of three HIV enzymes and mechanism of inhibition can be used to generate better drugs; in particular drugs that are effective against the current drug-resistant strains of HIV-1 and HIV 2 via structure prediction analysis of three HIV enzymes present their different activities as given tables. Computational protein modeling is a method designed for the most probable 3D structure from a sequence given its lignments with related structure .In this topic we discuss about the three HIV partner enzymes structure of HIV1and HIV2 from different software’s and their variations in core value, hydrophobicity, residues and intermolecular forces. Finally In this project we developed remodeled structures of different parameters mechanism in different core HIV enzymes partners with different types of functional structure prediction based on computational arithmetical calculations.
Keywords: Protease; Reverse Transcriptase; Integrase; HIV
