Evaluation of Thyroid Antibodies and Thyroid Stimulating Hormone Level in Cases of Recurrent Early Pregnancy Loss

Authors:

Galal HM¹, Azzam AZ¹, Elmahdy M¹*, Osama A¹ and Elsayed ET²

Volume 2, Issue 1

Abstract

Background: Autoimmune Thyroid Disease (AITD) is one of the most frequent causes of hypothyroidism in females during the fertile age. The prevalence of hypothyroidism in women in the reproductive age is about 2–3 %.

Objectives: Evaluate maternal anti-thyroid AB concentrations and TSH level in cases of recurrent miscarriage.

Patients and Methods: 400 female patients divided into two group’s. Group A: 200including women with history of early recurrent pregnancy loss. Group B: 200 women with at least 2 living children and without previous recurrent early pregnancy loss. Antithyroglobulin antibodies and anti-thyroid peroxides using chemiluminescence immunoassay (Normal level up to 115 IU/ml and up to 35 IU/ml) and TSH level using chemiluminescence immunoassay (Normal level 0,350- 2 IU/ml) were assessed.

Results: 10.0% and 9% of cases (n=200) and 3.0% and the same 3.0% of control group (n=200) were positive for anti TG antibodies and anti TPO antibodies. There was no statistically significant correlation between levels of anti TG antibodies and anti TPO antibodies and RPL (p= 0.052). 19 % of cases group showed abnormally high TSH level. On the other hand, 14% of control group showed high level TSH. There was no significant relation between recurrent pregnancy loss and abnormal TSH level (P= 0.34).

Conclusions: Neither TSH nor anti thyroid antibodies (ATG OR anti TPO) showed significant difference in cases with recurrent miscarriage.

Keywords:

Chemiluminescence; Antithyroglobulin; Anticardiolipin; Antithyroid

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