Therapeutic Potential of Aegle marmelos (Linn.) Leaves in Alloxan Monohydrate Induced Type-1 Diabetes in Experimental Rats

Authors: Sanjeev K*, Kumari S and Nayan KP

DOI: 10.23880/doij-16000235

Volume 5, Issue 4

Abstract

Present study was aimed to evaluate the anti-diabetic activity of Aegle marmelos in Alloxan monohydrate induced albino rats. Oral administration of fresh Aegle marmelos leaves (2 - 4 g/day) for 28 days shows significant blood glucose lowering effect in experimental alloxan induced diabetic rats. These diabetic rats blood glucose level became normal when fed with Aegle marmelos leaves. It is amply revealed that Aegle marmelos leaves possessed anti-diabetic and beta cells restoration properties. The results suggest that statistically significant anti-diabetic potential in alloxan monohydrate induced diabetic rats. The Aegle marmelos leaves to be almost similar effect like insulin treatment in alloxan monohydrate administered experimental animal model. From the present study it appeared that Aegle marmelos might have some key ingredients to increase the output of insulin by binding to the receptors of the Beta cells of the Langerhans located in the pancreas. Once they bind to the Sulphonyl urea receptors, the K+ -ATP channels are probably closed and therefore the membrane is depolarized and insulin production is stimulated. During the course of study, Aegle marmelos leaves fed experimental animals were normal blood glucose levels compared to insulin treated animals.

Keywords: Blood Glucose; Insulin; Aegle marmelos Leaves; Diabetes

View PDF