The Hypocholesterolemic and Glucose Modulatory Effect of Fibre Enriched Snack in Hyperlipidemic/Hyperglycemic Rat Model Induced by High Cholesterol and High Fructose Diet

Authors: Adetoboye OO*, Osibanjo A, Erukainure O, Obode O, Eboagwu I, Familola O, Odega J, Odega J, Oke O, Olonode T, Oluwole O and Elemo G

Volume 6, Issue 1

Abstract

Dietary interventions have been used in the management of hyperlipidemia. Incorporation of dietary fibre into food products enhances their nutritional value. This study was done to investigate the effect of a fibre enriched snack on the blood glucose level and lipid profile in hyperlipidemia-hyperglycemia - induced wistar albino rats. The rats (n=25) were divided into 5 groups, 1 - fed standard laboratory diet (Control), 2 - fed hyperlipidemic diet and 10% fructose solution, 3 - fed hyperlipidemic diet, 10% fructose solution alongside fibre enriched snack, 4- fed hyperlipidemic diet which was withdrawn before feeding fibre enriched snack, 5 - fed standard laboratory diet and fibre enriched snack, 6 - fed hyperlipidemic diet, 10% fructose solution and a conventional antilipemic drug (CAD). The duration of the experiment was for 6 weeks. Statistical analysis was done using graph pad prism 6.01 version. At the end of the experiment, it was found that the fibre enriched snack stabilized blood glucose levels, reduced serum total cholesterol (TC) (p<0.01) and low density lipoproteins (LDL) (p< 0.01) in the hyperlipidemic diet fed group. There was, however, no significant change in the triglycerides (TG) as well as the high-density lipoproteins (HDL) in the hyperlipidemic group fed with the fibre enriched snacks. The results indicate that the fibre enriched snack has hypoglycemic and hypolipidemic potential and could, therefore, serve as an effective dietary intervention in the management of diabetic dyslipidemia

Keywords: Antilipemic; Dietary; Cholesterol; Diabetic; Fibre; Glucose

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