ISSN: 2574-7800
Authors: Sooho Choi*, Yoonjeong Hwang, Taejun Kim and Jeong Hoon Kim
Oxidative stress is one of the leading causes of various diseases. Antioxidants are effective against reactive oxygen species (ROS), a major factor in oxidative stress. Antioxidants play important roles in our body by scavenging free radicals, thereby preventing them from damaging biological molecules. Vitamin C is essential for various physiological functions such as the synthesis of collagen and neurotransmitters, and it is a major antioxidant. Although vitamin C is widely used in cosmetic and therapeutic products, it easily undergoes oxidation by air, pH, temperature, and UV light, thereby decreasing its potency as an antioxidant and reducing the shelf-life of products containing vitamin C. To overcome this drawback, we developed Aptamin C®, an innovative single-strand DNA aptamer that maximizes the antioxidant efficacy of vitamin C by binding to its reduced form and delaying its oxidation. To investigate the effect of Aptamin C® and vitamin C complex on human skin, we performed both in vitro and clinical tests. We observed that the Aptamin C® and vitamin C complex had effective ROS-scavenging and anti-inflammatory effects.
Keywords: Aptamin C®; Vitamin C; Keratinocyte; DNA aptamer; Human skin
