Acoustic Range Electric-Magnetic Field Exposure Decreases Cortical Excitability in Genetically Epilepsy-Prone Rats

Authors: Nato B*, Giorgi K, Marina B, Lamara M and Militsa S

DOI: 10.23880/ijbp-16000109

Volume 2, Issue 1

Abstract

In the present study, we examined the effect of acoustic range of electric-magnetic field (EMF) on the behavioral manifestation of seizure in genetically epilepsy-prone rats (GEPRs) of Krushinsky-Molodkina strain. A 5-days exposure to EMF (10000 -15000 Hz frequency, 1.5 m/Tesla, during 20 min) resulted in partial or complete suppression of behavior seizure activity in GEPRs. Besides, on the background of EMF the latency period of first wild run was increased. On the same conditions, duration of wild run decreased. Audiogenic stimuli obtained in GEPRs changed the ECoG activity of sensomotoral cortex only in audiogenally-kindled animals. Findings of this study suggest that the regulation of the behavioral manifestation of seizure in GEPRs does not involve the cortex; it is mainly regulated by brainstem structures. We concluded that acoustic range of EMF could apply for suppression of behavioral manifestation of seizure. Audiogenic stimuli obtained in GEPRs changed the ECoG activity of sensomotoral cortex only in audiogenally-kindled animals. Findings of this study suggest that the regulation of the behavioral manifestation of seizure in GEPRs does not involve the cortex; it is mainly regulated by brainstem structures. Rostral part of cortex has significant role in manifestation of seizure activity in audiogenly kindling GEPRs. We concluded that acoustic range of EMF could apply for suppression of behavioral manifestation of seizure.

Keywords:

Electric-Magnetic Field; Seizure; Rats; ECoG

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